Please review this article below again as it addresses your issues! So I would not put too much false hope on the aneuploid embryos you have. XX, -18. • Blastocyst Embryo Transfers done 5-6 Days Following Fertilization are Fast Replacing Earlier day 2-3 Transfers of Cleaved Embryos. 4. We were woundering if it would be safe to tranfer (03-Ab abnormal +1s) along with a normal embryo we are really struggling with this decision we don’t want to disgarded a embryo when it could potentially be a healthy baby!!! This is one reason why “mosaicism” is more commonly detected in early embryos than in blastocysts. diminished ovarian reserve (DOR). I see some trisomies can be transferrable possibly in other cases. I’m 39. Complex abnormal +9p, -16 (female) Dr. Sheri, 4. trisomy 21/18, etc.) I would consider transferring all!Human embryo development occurs through a process that encompasses reprogramming, sequential cleavage divisions and mitotic chromosome segregation and embryonic genome activation. or, by Karin Hammarberg and David Amor, The Conversation. I am 40 years old. Pre-implantation genetic testing for aneuploidy (chromosome abnormalities), known as PGT-A, is an "add on" used to help choose embryos with the right number of chromosomes. Thanks so much for your help. This is why when it comes to giving consideration to transferring trisomic embryos, suspected of being “mosaic”, I advise patients to undergo prenatal genetic testing once pregnant and to be willing to undergo termination of pregnancy in the event of the baby being affected. Since then PGS has grown dramatically in popularity such that it is now widely used throughout the world. Could you please explain what makes this embryo complex abnormal? I have three egg retrievals with PGS. We recently received our results the addition (duplication) or subtraction (deletion), are also more likely to autocorrect. My clinic in NY doesn’t allow abnormal embryos transfers unfortunately. • IVF outcome: How Does Advancing Age and Diminished Ovarian Reserve (DOR) Affect Egg/Embryo “Competency” and How Should the Problem be addressed.

For confirmation and clarification, although I am currently 44 years old, during the time of my three respective PGS tested IVF egg retrievals I was two years younger and 42 years old as this occurred two years ago in 2018. Of course I would get the amniocentesis if it led to a pregnancy. Meiotic aneuploidy will thus invariably be perpetuated in all the cells of the embryo as they replicate. The same applies to the transfer of trisomic embryos where up to 2 autosomes are involved. I would consider transferring #s 5 and 6. Since meiosis occurs in the pre-fertilized egg or in and sperm, it follows that when aneuploidy occurs due to defective meiosis, all subsequent cells in the developing embryo/blastocyst/conceptus inevitably will be aneuploid, precluding subsequent “autocorrection”. 2. Thus by discarding aneuploid embryos the possibility exists that we could be denying some women the opportunity of having a baby. Thank you for your work. Yes! We have our last blast – a Day 5, hatching blast. 46,xx, -11,+12,+14,-19. 3. “Mosaic” (mitotically aneuploid) autosomally monosomic embryos where a chromosome is missing), can and often will “autocorrect” in-utero and propagate a viable pregnancy. So it is that older women as well as those who (regardless of age) have DOR have a reduced potential for IVF success.

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